(018) Negative Perceptions Among Young Adult Males Towards Antidepressants and Their Sexual Side Effects: A Case For Atypical Agents?

Abstract Introduction The prevalence of depression and anxiety among young adults (YA) rose precipitously in the last decade, along with a rise provision first-line antidepressants known as selective serotonin reuptake inhibiters (SSRIs). SSRIs are associated extremely high rates nonadherence - above 50% for all patients accentuated those under 35 years old. Concurrently, sexual dysfunction is estimated to affect many 65% treated an SSRI. Despite this, association between medication YA males has been poorly characterized. Further, there limited research comparing opinions YAs towards newer, effective, function-sparing like Bupropion Mirtazapine. Objective To determine if less willing adhere antidepressant treatment due intolerable side effects, such dysfunction. Moreover, characterize attitudes first- second-line antidepressants. Methods A cross-sectional, deidentified, compensated survey was designed using Qualtrics XM (Provo, UT). participation flyer distributed via social media recruit biological ages 18 35. Participants were asked indicate their perceptions three deidentified medications (SSRI-class, Bupropion, Mirtazapine) after being prompted most common effects. Respondents also rated potential negative impact effects (1=no impact; 10=worst possible impact) whether these experienced weekly, would trigger nonadherence. Parametric statistical tests conducted Stata (College Station, TX). Results From 665 surveys delivered email, we received 505 completed forms (response rate: 76%), which 486 included excluding submitted 180 seconds. Age normally mean 27.4 (SD: 3.6). 40% non-white, 21% LGBTQ+, 89% sexually active. majority our respondents employed full-time (60%), while 36% graduate or undergraduate students. As illustrated by Figure 1, participants' willingness take Mirtazapine significantly greater than SSRI when compared paired t-test (P<0.0001) no significant difference atypical agents (P=0.26). 73% preferred (P<0.0001). Additionally, erectile (6.2) anorgasmia (6.0), scored higher other weight gain (5.4), nausea (5.3), dry mouth (4.8). Finally, participants indicated that experiencing any weekly taking lead at frequency effect assessed (erectile dysfunction: 71%; anorgasmia: low libido: 70%). Conclusions knowledge, study largest investigation date males’ medications. Our findings risk could become nonadherent mental illness suicide continue dramatically males, strategies augment effectiveness antidepressants, shared decision-making use agents, critical. Disclosure Any authors act consultant, employee shareholder industry for: Dadi, Teleflex, Lina.